Organic chemistry in drug discovery.

Microwave-assisted high-speed chemistry: a new technique in drug discovery.

In both lead identification and lead optimization processes there is an acute need for new organic small molecules. Traditional methods of organic synthesis are orders of magnitude too slow to satisfy the demand for these compounds. The fields of combinatorial and automated medicinal chemistry have been developed to meet the increasing requirement of new compounds for drug discovery; within the...

Microwave-Assisted Pharmaceutical Synthesis: An Overview

Microwave-assisted organic synthesis is an enabling technology for accelerating drug discovery and development processes. Microwave instruments are used principally in three areas of drug research: the screening of organic drug formulae, peptide synthesis, and DNA amplification. The features of microwave-assisted organic synthesis technology include reduction of time for a chemical reaction, in...

Combinatorial chemistry.

Patents of bio-active compounds based on computer-aided drug discovery techniques.

In recent times, there has been an increased use of Computer-Aided Drug Discovery (CADD) techniques in Medicinal Chemistry as auxiliary tools in drug discovery. Whilst the ultimate goal of Medicinal Chemistry research is for the discovery of new drug candidates, a secondary yet important outcome that results is in the creation of new computational tools. This process is often accompanied by a l...

Rational drug design, medicinal chemistry, planned serendipity and the impact of automation on the drug discovery process

This paper examines the processes by which new drug candidates are discovered, especially the early stages of this discovery process. Excluding compounds that are licensed-in, three distinct sources of lead compounds are generally recognized: Medicinal chemistry. Empirical screening.